Liver failure and transplantation after itraconazole treatment for toenail onychomycosis.
نویسندگان
چکیده
Three weeks after completing a 4-pulse course of itraconazole for toenail onychomycosis, a 25-year-old woman patient developed severe liver crisis and required an emergency liver transplant. We report the case and discuss the use of itraconazole in onychomycosis and dermatomycoses.
منابع مشابه
A case of toenail Onychomycosis with Scopulariopsis Brevicalis
During 12 months survey on 33 patients with onychomycosis, only one of them showed infection due to scopulariopsis brevicalis. The case was a 38-year-old male with great toe nail lesion which was diagnosed as Trichophyton rubrum based on smear and culture. The patient was treated with 3 weekly pulses of itraconazole, 200mg twice daily during 3 months and showed marked clinical improvement. But ...
متن کاملPharmacoeconomic analysis of oral therapies for onychomycosis: a US model.
An evaluation of treatment practices in 13 countries, not including the United States, has shown oral terbinafine to be more cost-effective (from a government payer perspective) than griseofulvin, itraconazole, and ketoconazole in the treatment of onychomycosis of toenails and fingernails. The purpose of this study was to evaluate the clinical and economic effects of oral griseofulvin, itracona...
متن کاملEconomic evaluation of antifungal agents in the treatment of toenail onychomycosis in Germany.
BACKGROUND The strategies for the management of onychomycosis have changed since the availability of the newer generation of antifungal agents, particularly, itraconazole and terbinafine. Itraconazole (1-week pulse) therapy may have higher efficacy and an improved adverse-effects profile compared to the continuous therapy regimen. OBJECTIVE We performed a pharmacoeconomic evaluation of the mo...
متن کاملDouble blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis. The LION Study Group.
OBJECTIVE To compare the efficacy and safety of continuous terbinafine with intermittent itraconazole in the treatment of toenail onychomycosis. DESIGN Prospective, randomised, double blind, double dummy, multicentre, parallel group study lasting 72 weeks. SETTING 35 centres in six European countries. SUBJECTS 496 patients aged 18 to 75 years with a clinical and mycological diagnosis of d...
متن کاملRandomized double-blind comparison of short-term itraconazole and terbinafine therapy for toenail onychomycosis.
Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n = 146) or terbinafine 250 mg daily (n = 146) for 12 weeks, with a 36-week follow-up. Mycological cure rat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of the European Academy of Dermatology and Venereology : JEADV
دوره 19 2 شماره
صفحات -
تاریخ انتشار 2005